• Is there a pre-existing autoimmune dysfunction?
  • Is there a history of prior orthopedic injury, DJD, OA, RA?
  • Other immune-related adverse effects
  • Three subtypes of inflammatory arthritis associated with checkpoint inhibitors:
    1. Polyarthritis similar to rheumatoid arthritis
    2. True reactive arthritis with conjunctivitis, urethritis, and oligoarthritis
    3. Subtype similar to seronegative spondyloarthritis with inflammatory back pain and predominantly larger joint involvement
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